Journal of Neuroscience
Elevated Lamin B1 in Neurons Made from Human Dystonia Cells
Baojin Ding, Yu Tang, Shuaipeng Ma, Masuma Akter, Meng-Lu Liu, et al.
(see pages 2024–2038)
January 29, 2022
Congratulations to the Ding Lab that the publication (Ding et al. Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystonia. J Neurosci. (2021) 41 (9): 2024-2038.) was selected as JNeurosci Spotlight 2021.
JNeurosci's Annual Spotlight features articles that received the highest marks for both methodological merit and significance. See the papers selected for this year’s recognition.
January 27, 2022
Research Features: Patient-specific neurons key in new dystonia discoveries. PDF
January 4, 2022
Congratulations to the Ding Lab on moving to the new institution, Louisiana State University Health Sciences Center School of Medicine at Shreveport (LSU Health Shreveport). The new lab localizes on the 7th floor in the Biomedical Research Institute (BRI) building on the campus.
August 5, 2021
Congratulations to Masuma for receiving the Student Government Association (SGA) International Friendship Non-Endowed Scholarship for the 2021-2022 school year from UL Lafayette.
July 21, 2021
Congratulations to Casey for passing his Master proposal defense!
July 2, 2021
Congratulations to Masuma for passing her Ph.D. proposal defense!
February 12, 2020
Congratulations to the Ding Lab on receiving a grant from the National Institutes of Health (NIH). This is the National Institute of Neurological Disorders and Stroke (NINDS) Exploratory Neuroscience Research Grant. The project aims to determine the pathogenesis of childhood-onset DYT1 dystonia in patient-specific neurons that are generated by direct conversion and iPSC-based reprogramming and differentiation.
November 15, 2019
Congratulations to the Ding Lab on receiving a grant from the Department of Defense (DoD) Peer-Reviewed Medical Research Program (PRMRP) Discovery Award. This project aims to determine the pathogenesis of adulthood onset dystonia via directly reprogramming human neurons from patient fibroblasts.
Figure: Lamin B1 (green) is localized to the nucleus (blue) in motor neurons (red) derived from control human fibroblasts (A), but is mislocalized to the neurites of neurons derived from DYT1 patient fibroblasts (B). See Ding et al for details.